By Pekka Lappalainen
The actin cytoskeleton performs a vital function in lots of mobile tactics together with mobile motility, cytokinesis, endocytosis and phagocytosis. The constitution and dynamics of the actin cytoskeleton is regulated by means of a great number of proteins that have interaction with monomeric and/or filamentous actin. Actin monomer binding proteins presents a entire view on actin monomer-binding proteins and the mechanisms wherein they give a contribution to actin dynamics and numerous actin-dependent mobile methods. This new name includes chapters that describe the elemental mechanisms of actin dynamics in addition to the structural rules in which quite a few actin-binding proteins have interaction with actin.
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Hayden SM, Miller PS, Brauweiler A et al. Analysis of the interactions of actin depolymerizing factor widi G- and F-aain. Biochemistry 1993; 32(38):9994-10004. 29. Bobkov AA, Muhlrad A, Pavlov DA et al. Cooperative effects of cofilin (ADF) on actin structure suggest allosteric mechanism of cofilin fiinction. J Mol Biol 2006; 356(2):325-334. 30. Bamburg JR, McGough A, O n o S. Putting a new twist on actin: ADF/cofilins modulate actin dynamics. Trends Cell Biol 1999; 9(9):364-370. 31. Chen H , Bernstein BW, Bamburg JR.
Jang D H , Han J H , Lee SH et al. Cofilin expression induces cofilin-actin rod formation and disrupts synaptic structure and function in Aplysia synapses. Proc N a t l Acad Sci USA 2 0 0 5 ; 102(44):16072-16077. 143. Aizawa H , Kishi Y, lida K et al. Cofilin-2, a novel type of cofiHn, is expressed specifically at aggregation stage of Dictyostelium discoideum development. Genes Cells 2 0 0 1 ; 6(10):913-921. 144. Bowman G D , Nodelman IM, H o n g Y et al. A comparative structural analysis of the ADF/cofilin family.
The sulphate (S) in the second PIP2 site (PIP2||) is also illustrated (red and yellow). See text for references and details. Illustrations were made in Molsoft ICM Browser. should be of interest. The principal features of the profilin fold are also found in the endosomal adaptor protein p l 4 and in members of a snare subfamily, the longins, which indicates that these proteins may express some of the functions of profilin. ' Poly-(L-Proline) and Profilin The discovery that profilin binds poly-(L-proline) was used to develop a fast procedure for the isolation of profilin and profiliniactin based on affinity chromatography on poly-(L-proline).