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By J.H.U. Brown, James Francis Dickson

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PARAMETERS IN THE DESIGN OF THERAPEUTIC SYSTEMS Spatial constraints in the design of a therapeutic system are obvious but nevertheless worth emphasizing. The system must be carried by the pa­ tient comfortably and inconspicuously if it is to be acceptable. The sys­ tems must be minimally interactive at their biological interface, and they must be compatible with the drugs being administered. They must pro­ vide stability for the drug in their reservoir, and the whole system may have to be sterile.

Stream­ ing potential and electroosmosis owe their existence to the electrical dou­ ble layer. Electroosmosis is observed when an electrical potential is ap­ plied to opposite ends of a porous plug in a liquid medium. A flow of liquid through the plug occurs. The streaming potential is the converse. Forced motion of liquid through a porous plug generates an electrical potential. The utility of such phenomena described above is that they offer a means by which the shape of the electrical double layer can be inferred from the characteristic potential developed, called the zeta potential.

L. (1968). J. Allergy 41, 49. , and Kornreich, M. (1970). In "Research in Psychotherapy" (J. Meltzoff and M. ), p. 3. Aldine, Chicago, Illinois. Michaels, A. , and Chandrasekaran, S. K. (1975). E. J. In press. 34 F. E. YATES ET AL. , and Zaffaroni, A. (1974). Fert. Steril. 25, 915. , and Pharriss, B. (1974). J. Reprod. Med. 13, 66. Reinberg, A. (1973) In "Biological Aspects of Circadian Rhythms" (J. N. ), p. 121. Plenum, New York. Ryder, N. B. (1973). Family Pfon. Perspect. 5, 133. , and Ross, L.

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