By P Brandtzaeg, K Bjerke, T S Halstensen, M Hvatum, K Kett, P Krajci, D Kvale, F Müller (auth.), Thomas T MacDonald PhD MRCPath, Stephen J Challacombe PhD BDS MRCPath, Paul W Bland PhD, Christopher R Stokes PhD, Richard V Heatley MD MRCP, Allan Mcl Mowat Ph
The immunology of mucosal surfaces is among the most enjoyable and correct components of clinical veterinary and dental study because it applies simple learn to tissues in volved in daily defence opposed to microbes and opposed to environmental and foodstuff antigens. This booklet is predicated at the contributions provided on the foreign Con gress of Mucosal Immunology, held in London in July 1989 and organised by means of the Mu cosal Immunology Affinity staff of the British Society for Immunology. The meet ing was once attended via over 500 delegates from 27 international locations, together with almost all the top investigators within the box. The contents supply complete and up-to date info on such subject matters as antigen presentation and processing within the intestine, mucosal vaccines in guy and animals, HIV an infection within the intestine, the position of yo T cells within the intestine epithelium, contemporary advances in inflammatory bowel disorder and coeliac dis ease, the function of cytokines within the legislation of the IgA reaction, mucosal mast cells and mobilephone migration. The contributions mirror the quick velocity of analysis in mucosal immunology, and the nice strides that are occurring within the realizing of the immunology, molecular biology and biochemistry of host reaction at mucosal sur faces.
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Extra info for Advances in Mucosal Immunology: Proceedings of the Fifth International Congress of Mucosal Immunology
1986) 'Spontaneous secretion of IgG subclasses by intestinal mononuclear cells: differences between ulcerative colitis, Crohn's disease, and controls', Clin. Exp. Immunol. 66, 209-215. O. and Brandtzaeg, P. (1987) 'Mucosal subclass distribution of immunoglobulin G-producing cells is different in ulcerative colitis and Crohn's disease of the colon', Gastroenterology 93, 919-924. , Mollnes, LE. and Brandtzaeg, P. (1989) Persistent complement activation in submucosal blood vessels of active inflammatory bowel disease: immunohistochemical evidence', Gastroentrology 97, 10-19.
We have recently confirmed this for human SC by cloning of its cDNA . Like other members of the Ig superfamily, SC expression can be regulated by lymphokines. Both recombinant interferon-r (IFN-r) and tumor necrosis factor-a (TNF-a) upregulate the intracellular pool and epithelial membrane expression of functional SC in the HT -29 cell line . The effects of these two cytokines on SC expression are additive in a dosedependent manner . IFN-r is secreted by T cells during immune responses whereas activated macrophages are the best recognized source of TNF -a.
The possibility that the TCRy/o+ IEL are cytotoxic and contribute to villous atrophy is a fascinating challenge for further research, but a putative contrasuppressive function should also be explored. Untreated coeliac lesions show increased epithelial expression of both SC and HLA-DR , most likely mediated by cytokines released from primed T cells and perhaps macrophages. Differential HLA class II expression in the jejunal epithelium is in fact related to the number of intraepithelial putative memory (CD45RO+) T cells, and positivity for DP and DQ is seen only when this number is high .