Download Bacterial Pili: Structure, Synthesis and Role in Disease by M.A. Barocchi, J.L. Telford PDF

By M.A. Barocchi, J.L. Telford

Bacterial pili play very important roles as environmental sensors, in host colonization and in biofilm formation, permitting micro organism to have interaction with the surroundings, with surfaces and with different micro organism and host cells. so much micro organism, either Gram confident and Gram unfavourable, and just about all bacterial pathogens, are piliated. This ebook discusses the synthesis, constitution, evolution, functionality and function in pathogenesis of those complicated buildings, and their foundation for vaccine improvement and therapeutics for Streptococcus pathogens. it's a useful source for researchers and scholars of scientific microbiology.

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Extra resources for Bacterial Pili: Structure, Synthesis and Role in Disease

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Additionally, most conjugation systems are assembled from a common set of protein ‘building blocks’ whose names, unfortunately, are specific to that system. This complicates comparisons of the different systems, so here we will use the A. tumefaciens VirB/VirD4 nomenclature as a reference point (AlvarezMartinez and Christie, 2009). Finally, as is also the case for the entire T4SS family, many conjugation systems have acquired novel domains, proteins or protein subassemblies during evolution that endow these systems with specialized functions.

2000). , 2000). g. TraN, or outermembrane-bound forms of pilins mediate mating junction formation. The inability to detect mating channels also raises the intriguing possibility that these channels form only transiently upon surface contact by donor and recipient cells. Interestingly, there is some evidence for DNA transfer through the F-pilus. For example, DNA transfer was shown to occur between cells that were separated by a filter (Harrington and Rogerson, 1990). , 2008). In a mixed population of donor and recipient cells fixed on a glass slide, DNA transfer could be detected in the absence of apparent donor–recipient cell contact.

VirB4-like subunits are signatures of all bacterial conjugation machines (Alvarez-Martinez and Christie, 2009), and thus might generally function as pilin dislocases early during morphogenesis of conjugative pili. 5 Latter-stage Pilus Assembly Once pilins are extracted from the membrane, how and where on the cell envelope do they polymerize? To address this question, it is C B5 F-pilus extension / retraction Mating pair stabilization B B2 B11 B4 pilin dislocase I N OM W U H F B I II IV III pro-pilin B2 pilin IM Membrane insertion TraN/TraO/TraF (B7/B9/B10) core complex TraV/K/B B10/B9/B7 B8 B6 Leader sequence cleavage / Terminal processing / Cyclization TraV/K/B B7/B9/B10 IM B7/B9/B10 OM OM TraG IM TraC Fig.

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