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By Jesse P. Greenstein (Auth.)

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DUNNING, W. , and BULLOCK, F. , Am. J. Cancer 17,894 (1933) (18) SELIGMAN, A. , and SHEAR, M. , Am. J. Cancer 37, 364 (1939) (19) Cf. HARTWELL, J. , Survey of Compounds Which Have Been Tested for Carcinogenic Activity (U. S. ) II. THE GENERAL PHENOMENA AND TAXONOMY OF CANCER 29 (20) TURNER, F . C , / . Natl. Cancer Inst. , BABCOCK, 11. , Am. J. Cancer 39, 56 (1940) (22) (23) (24) (25) (26) (27) ANDERVONT, H. , and SHIMKIN, M. , J. Natl. Cancer Inst. 1, 349 (1940) MCENDY, D . , BOON, M. , J. Natl.

An agent carcinogenically active in one species of animal may be inactive in another species. An agent may be active under some modes of administration and inactive under others. Thus, these and many other observations indicate that the carcinogenic potenc}' of an agent does not reside in the nature of the agent alone but is a function of the following factors: the dosage, the nature of the vehicle, the mode and length of time of administration of the agent; the strain, the species, the sex and the age of the test animals; the site of application, the presence of concomitant factors such as the level of essential dietary constituents and the number of animals kept in a cage, and perhaps still other as yet unknown conditions.

An agent carcinogenically active in one species of animal may be inactive in another species. An agent may be active under some modes of administration and inactive under others. Thus, these and many other observations indicate that the carcinogenic potenc}' of an agent does not reside in the nature of the agent alone but is a function of the following factors: the dosage, the nature of the vehicle, the mode and length of time of administration of the agent; the strain, the species, the sex and the age of the test animals; the site of application, the presence of concomitant factors such as the level of essential dietary constituents and the number of animals kept in a cage, and perhaps still other as yet unknown conditions.

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