By Yang Xia
This detailed ebook describes the newest info within the primary knowing of the biophysics and biochemistry of articular cartilage utilizing the state of the art practices in NMR and MRI. this is often the 1st booklet of its style, written by way of physicists and chemists in this very important tissue, whose degradation contributes to osteoarthritis and similar joint illnesses. Connecting the elemental technological know-how with the scientific imaging functions, the specialists Editors supply an authoritative addition to the literature.
Ideal for working towards actual scientists and radiologists with an curiosity within the primary technology in addition to software brands and scientific researchers operating with articular cartilage
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Additional info for Biophysics and biochemistry of cartilage by nmr and mri
1039/9781782623663-00001 182 cartilage.
It should be noted that some “primary” osteoarthritis patients might forget one or several sub-acute traumas or injuries many years earlier, which had actually contributed to the initial degradation of his or her cartilage and joint. 2 Pathogenesis The molecular mechanisms underlying the pathogenesis of osteoarthritis are still not fully understood and there is no widespread agreement. 179 Epigenetics has been implicated in osteoarthritis, with three known mechanisms, including DNA methylation, histone modifications and non-coding RNAs presenting a capacity to control the chondrocyte phenotype.
4a. In this chapter (and this book), the words "collagen", "collagen fibrils", and "collagen fibers" all refer interchangeably to this multi-scaled macromolecule and its supramolecular structure (the ECM). 4 (a) Schematic diagram of type I collagen fibril structure. Helical colla- gen molecules form from three polypeptide chains, and these associate laterally to form collagen fibrils with a characteristic banded structure. ) (b) Schematic diagram of proteoglycan aggregate macromolecule, depicting the glycosaminoglycan side-chains and the associated sulfated molecules (keratan sulfate and chondroitin sulfate).