By M. Adolphe
Advances in Pharmacology and Therapeutics, quantity 10: Chemotherapy covers the court cases of the seventh foreign Congress of Pharmacology. The name provides papers that element the development of pharmacological examine in chemotherapy.
The textual content first covers the chemotherapy of schistosomiasis. subsequent, the choice offers the tendencies in malaria and melanoma chemotherapy, in addition to their pharmacological learn. The textual content additionally info using cellphone cultures as instruments in pharmacological investigations.
The e-book could be of serious curiosity to pharmacologists and oncologists.
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Extra resources for Chemotherapy. Proceedings of the 7th International Congress of Pharmacology, Paris, 1978
Praziquantel is effective against S^mansoni in vitro at very low concentrations. 001 jug prazlqûân€êl7ml medium is sufficient to inhibit egg production. Accordingly, even the small dose of 5 mg/kg, therapeutically ineffective, already effect the oogram. 04 ;ug/ml. Our first efforts to characterize the mode of action of praziquantel concentrated on the parasites' carbohydrate metabolism. ~ïactate excretion. Praziquantel also induced a ^apid decrease in endogenous glycogen. These metabolic effects of praziquantel observed in vitro are probably secondary ones.
33 A. Prata REFERENCES 1. G. Provävel hepatite por oxamniquine. Apresentaçao de um caso. Resumo de Temas-Livres, pag. 122. XIV Cong. Trop. 1978. 2. A. 68, 1975. Hycanthone and the liver. Brasilia Med. 11: 65- 3. , CARRANO, H. S. Tratamento das infecçoes por Schistosoma mansoni em doentes portadores de tuberculose pulmonar internados no Sanatorio Sao Sebastiao - Lapa, Parana. Folha Med. 74: 387-390, 1977. 4. C. & PRATA, A. Tratamento da esquistossomose com oxamniquine (xarope) em crianças. Trop.
Against S ·_japonicTom in the vervet monkey a complete cure was obtained with 35~mg/kg""gïven on five consecutive days. _haematobium, S^jagonicum and S^mansoni. Histopathological studïês~shôwid"hât mâny"worms"âlso dïêd"ïn""sïtu in the mesenteric vessels, while only a few were found in the lung in §i-£â§2â£obium and S^mansoni infections. A predominant characteristic in the pathology of the monkeys given a curative dose of praziquantel was the total resolution of cellular reaction and fibrosis in the tissues containing known numbers of dead residual eggs (James et al.